Mouse models of human inherited facial dysmorphologies-Craniofacial Resource
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Leah Rae Donahue, Ph.D., Senior Research Scientist, Director of Genetic Resources
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Stephen A. Murray, Ph.D, Research Scientist
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Michelle M. Curtain, B.A., Research Assistant II
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Coleen C. Kane, Biomedical Technologist II
The aims of the Craniofacial Resource are to discover and characterize new craniofacial mouse mutations and to provide the scientific community with models for facial, dental, eye, ear and skull development research, as well as mouse models of human craniofacial syndromes. New deviants, which arise spontaneously among the millions of inbred mice produced yearly at The Jackson Laboratory, are shown twice a month at Deviant Search. Craniofacial deviants selected from those shown, are taken for study by members of the CF Resource. Deviants are tested for heritability, their craniofacial abnormality is characterized, and a linkage cross is made to determine the mutant gene's chromosomal location.
The Craniofacial Resource (CF Resource) began as the Animal Core of The Johns Hopkins University's Center for Craniofacial Development and Disorders (CCDD) with a grant awarded to Dr. Muriel Davisson. The CF Resource has now received independent funding and is an established resource based at The Jackson Laboratory. The Craniofacial Resource is supported by a grant awarded to The Jackson Laboratory by The National Eye Institute titled "Gene Discovery for Craniofacial Disorders" (RO1 EY 015073 - Dr. Leah Rae Donahue, PI).
See a list of our mapped mutations.
Other Resources offering craniofacial phenotypes
