Mouse models of human inherited facial dysmorphologies - Craniofacial Resource
The aims of the Craniofacial Resource are to discover and characterize new craniofacial mouse mutations and to provide the scientific community with models for facial, dental, eye, ear and skull development research, as well as mouse models of human craniofacial syndromes. New deviants, which arise spontaneously among the millions of inbred mice produced yearly at The Jackson Laboratory, are taken for study by members of the Craniofacial Resource. Our group also manages the production of large numbers of ENU-mutagenized mice, which provides an additional source of craniofacial deviants. Deviants are tested for heritability, their craniofacial abnormality is characterized, and a linkage cross is made to determine the mutant gene's chromosomal location.
See a list of our mapped mutations. Our goal is to make these spontaneous mutants as useful as possible to the research community. Toward that effort, we may continue to work on any of these posted mutants and will contribute additional data as collected.